Omphalotus subilludens

Omphalotus subilludens
Scientific classification
Kingdom: Fungi
Division: Basidiomycota
Class: Agaricomycetes
Order: Agaricales
Family: Marasmiaceae
Genus: Omphalotus
Species: O. subilludens
Binomial name
Omphalotus subilludens
(Murrill) H.E. Bigelow 1982
Synonyms

Clitocybe subilludens (Murrill) Murrill 1945[1]
Monodelphus subilludens Murrill 1945

Omphalotus subilludens is a fungus species in the genus Omphalotus.

Atromentin and thelephoric acid are chemical compounds found in cultures of C. subilludens.[2] Atromentin is an effective anticoagulant, and similar in biological activity to the well-known anticoagulant heparin.[3] Atromentin also possesses antibacterial activity, inhibiting the enzyme enoyl-acyl carrier protein reductase (essential for the biosynthesis of fatty acids) in the bacteria Streptococcus pneumoniae.[4]

It also produces illudoids.[5]

References

  1. ^ Murrill, W.A., 1945, Quarterly Journal of the Florida Academy of Science 8(2): 198
  2. ^ Occurrence of atromentin and thelephoric acid in cultures of clitocybe subilludens. G. Sullivan, R. D. Garrett and R. F. Lenehan, Journal of Pharmaceutical Sciences, Volume 60, Issue 11, November 1971, pages 1727–1729, doi:10.1002/jps.2600601134, PubMed
  3. ^ Khanna JM, Malone MH, Euler KL, Brady LR. (1965). "Atromentin – anticoagulant from Hydnellum diabolus". Journal of Pharmaceutical Science 54 (7): 1016–20. doi:10.1002/jps.2600540714. PMID 5862512. 
  4. ^ Zheng CJ, Sohn MJ, Kim WG. (2006). "Atromentin and leucomelone, the first inhibitors specific to enoyl-ACP reductase (FabK) of Streptococcus pneumoniae". Journal of Antibiotics 59 (12): 808–12. doi:10.1038/ja.2006.108. PMID 17323650. 
  5. ^ Illudoids from Omphalotus olivascens and Clitocybe subilludens. Nair M. S. R., Carey S. T. and Rogerson C. T., Mycologia, 1983, vol. 75, no5, pages 920-922, INIST:9415717

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